As part of the Department of Physical and Applied Sciences, the mission of the Applied Science program coincides with the entire Madonna University mission regarding career preparation, and service to others and society based on Judeo-Christian principles as advanced by the Felician Sisters. The Applied Science program incorporates this mission while also making a strong commitment to liberal arts education.

Though focusing on science in particular, the sciences are taught with a global perspective, incorporating the role of Applied Science applications in social, environmental, ethical and human issues.